Neuronal activity of the zona incerta in Parkinson's disease patients
Identifieur interne : 003325 ( Main/Exploration ); précédent : 003324; suivant : 003326Neuronal activity of the zona incerta in Parkinson's disease patients
Auteurs : Marcelo Merello [Argentine] ; Eduardo Tenca [Argentine] ; Daniel Cerquetti [Argentine]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-07.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Artifacts, Basal ganglion, Brain Mapping, Dominance, Cerebral (physiology), Electroencephalography, Evoked Potentials (physiology), Female, Fourier Analysis, Human, Humans, Male, Microelectrodes, Microsurgery, Middle Aged, Nervous system diseases, Neurologic Examination, Neuronavigation, Neurons (physiology), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Parkinson disease, Parkinson's disease, STN, Signal Processing, Computer-Assisted, Software, Subthalamic Nucleus (physiopathology), Subthalamic Nucleus (surgery), Subthalamus (physiopathology), Subthalamus (surgery), Zona incerta, basal ganglia, microrecording.
- MESH :
- physiology : Dominance, Cerebral, Evoked Potentials, Neurons.
- physiopathology : Parkinson Disease, Subthalamic Nucleus, Subthalamus.
- surgery : Parkinson Disease, Subthalamic Nucleus, Subthalamus.
- Aged, Artifacts, Brain Mapping, Electroencephalography, Female, Fourier Analysis, Humans, Male, Microelectrodes, Microsurgery, Middle Aged, Neurologic Examination, Neuronavigation, Signal Processing, Computer-Assisted, Software.
Abstract
The objective of this study was to describe the firing characteristics of the zona incerta (ZI) in Parkinson's disease patients. The ZI constitutes a band of gray matter lying dorsal to the subthalamic nucleus, whose firing properties have not been well defined in humans yet. ZI proved to become hyperactive in 6‐OHDA–lesioned rats as compared to normal rats, and regarding these noticeable changes in the discharge patterns it was suggested that ZI could be a putative target for the surgical treatment of Parkinson's disease. Twelve patients who underwent microrecording‐guided subthalamic surgery consented to the study. Neurons from different tracts were classified as belonging to the ZI according to their firing features, background extracellular activity, anatomical mapping of trajectories, and atlas confirmation. Fifty‐nine neurons were classified as belonging to ZI. The mean firing rate proved to be 29.5 Hz, with a broad dispersion band, even covering subthalamic nucleus (STN) frequency ranges. Pattern analysis showed heterogeneous neuronal signals ranging from tonic to burst and paused neurons. A decrease in extracellular background activity in the defined ZI was also observed. Five of the recorded neurons showed rhythmical spike trains with oscillations of 8 to 14 Hz, and two units were found to discharge trains at 4 Hz. None of the recorded ZI neurons responded to proprioceptive maneuvers. ZI presented firing activities with a broad spectrum in terms of frequency and tonicity. It is differentiated from STN recordings in Parkinson's disease patients mainly because of absent proprioceptive‐related units and diminished extracellular background activity. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.20834
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-07">2006-07</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="937">937</biblScope><biblScope unit="page" to="943">943</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">77138A0B33CB213A54BAB5903D0D9F14FF47F0AB</idno><idno type="DOI">10.1002/mds.20834</idno><idno type="ArticleID">MDS20834</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Artifacts</term><term>Basal ganglion</term><term>Brain Mapping</term><term>Dominance, Cerebral (physiology)</term><term>Electroencephalography</term><term>Evoked Potentials (physiology)</term><term>Female</term><term>Fourier Analysis</term><term>Human</term><term>Humans</term><term>Male</term><term>Microelectrodes</term><term>Microsurgery</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Neurologic Examination</term><term>Neuronavigation</term><term>Neurons (physiology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (surgery)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>STN</term><term>Signal Processing, Computer-Assisted</term><term>Software</term><term>Subthalamic Nucleus (physiopathology)</term><term>Subthalamic Nucleus (surgery)</term><term>Subthalamus (physiopathology)</term><term>Subthalamus (surgery)</term><term>Zona incerta</term><term>basal ganglia</term><term>microrecording</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dominance, Cerebral</term><term>Evoked Potentials</term><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Subthalamic Nucleus</term><term>Subthalamus</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term><term>Subthalamic Nucleus</term><term>Subthalamus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Artifacts</term><term>Brain Mapping</term><term>Electroencephalography</term><term>Female</term><term>Fourier Analysis</term><term>Humans</term><term>Male</term><term>Microelectrodes</term><term>Microsurgery</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Neuronavigation</term><term>Signal Processing, Computer-Assisted</term><term>Software</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Homme</term><term>Noyau gris central</term><term>Parkinson maladie</term><term>Système nerveux pathologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to describe the firing characteristics of the zona incerta (ZI) in Parkinson's disease patients. The ZI constitutes a band of gray matter lying dorsal to the subthalamic nucleus, whose firing properties have not been well defined in humans yet. ZI proved to become hyperactive in 6‐OHDA–lesioned rats as compared to normal rats, and regarding these noticeable changes in the discharge patterns it was suggested that ZI could be a putative target for the surgical treatment of Parkinson's disease. Twelve patients who underwent microrecording‐guided subthalamic surgery consented to the study. Neurons from different tracts were classified as belonging to the ZI according to their firing features, background extracellular activity, anatomical mapping of trajectories, and atlas confirmation. Fifty‐nine neurons were classified as belonging to ZI. The mean firing rate proved to be 29.5 Hz, with a broad dispersion band, even covering subthalamic nucleus (STN) frequency ranges. Pattern analysis showed heterogeneous neuronal signals ranging from tonic to burst and paused neurons. A decrease in extracellular background activity in the defined ZI was also observed. Five of the recorded neurons showed rhythmical spike trains with oscillations of 8 to 14 Hz, and two units were found to discharge trains at 4 Hz. None of the recorded ZI neurons responded to proprioceptive maneuvers. ZI presented firing activities with a broad spectrum in terms of frequency and tonicity. It is differentiated from STN recordings in Parkinson's disease patients mainly because of absent proprioceptive‐related units and diminished extracellular background activity. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Argentine</li></country></list><tree><country name="Argentine"><noRegion><name sortKey="Merello, Marcelo" sort="Merello, Marcelo" uniqKey="Merello M" first="Marcelo" last="Merello">Marcelo Merello</name></noRegion><name sortKey="Cerquetti, Daniel" sort="Cerquetti, Daniel" uniqKey="Cerquetti D" first="Daniel" last="Cerquetti">Daniel Cerquetti</name><name sortKey="Tenca, Eduardo" sort="Tenca, Eduardo" uniqKey="Tenca E" first="Eduardo" last="Tenca">Eduardo Tenca</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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